The 2021 Precision Health Virtual Summit serves to showcase how advances in data-driven care by Precision Health Insight Networks (PHINs) are reducing overwhelming complexity in our care delivery system. Historically, the information clinicians required to deliver personalized, precise care was locked away in disconnected databases, buried in medical journals and isolated in multiple patient data silos. PHINs enable healthcare providers to uncover actionable insights in real-time to identify the right testing and prescriptions for optimal outcomes at the lowest cost.