Disparate information systems hampered doctors, nurses and administrators as they cared for critical-care patients with unique medical histories and lifestyles. The lack of access to patients’ data, including medical histories and lab test results, significantly slowed efforts to provide the best care and, in turn, potentially save more lives. Cross-collaboration between technology, health care, business and government leaders would have ensured doctors had relevant, real-time data to make the best decisions for patients. A connected, cloud-based system, or a Precision Health Insight Network (PHIN), would have also provided a clear path to improve the U.S. healthcare system overall. To fully embrace the lessons learned and prevent another breakdown in health care response, leaders in health care, government, and technology industries must collaborate to properly prepare in the future. Among the challenges this pandemic laid bare — and the solutions below to avoid the unknown in the future — supply a blueprint to care for a large population and the intricacy of individual communities through a PHIN.